Have questions about EQUIOXX?You’ve come to the right place.

We’ve compiled a comprehensive list of answers to questions we hear the most. Browse our FAQ library, and
if you still can’t find what you’re looking for, visit the Contact Us section. We’ll be glad to help.

ABOUT EQUIOXX

NSAID stands for Non-Steroidal Anti-Inflammatory Drug. NSAIDs are primarily used to treat inflammation and mild to moderate pain. Other common NSAIDs for horses are phenylbutazone (bute) and Banamine® (flunixin meglumine).

EQUIOXX is the first non-steroidal anti-inflammatory drug (NSAID) of the coxib class used to control pain and inflammation associated with osteoarthritis in horses that has been approved for use in the U.S. As a coxib class NSAID, EQUIOXX targets COX-2 (cyclooxygenase-2), which helps generate chemicals called prostaglandins that are responsible for pain and inflammation, while sparing COX-1 (cyclooxygenase-1), which helps maintain normal bodily functions such as blood flow to the kidneys and gastric mucosal protection.*

Most NSAIDs currently approved for use in horses inhibit both COX-1 and COX-2. Firocoxib, the active ingredient in EQUIOXX Brand Products is a highly selective inhibitor of COX-2.**

*Clinical relevance has not been determined.
**Not a claim of superiority.

EQUIOXX comes in an injectable formulation as well as a paste and chewable tablet.

EQUIOXX provides consistent pain relief* for 24 hours with just one daily dose.1 Multiple daily-dosing required of other products can result in a roller-coaster effect of pain and pain relief.2

* Joint pain and inflammation associated with equine osteoarthritis, also called degenerative joint disease.

  1. EQUIOXX product labels.
  2. Phenylbutazone Tablets, Le Sueur, MN: Vet One, 2006.

EQUIOXX Injection is administered in a small dose of 2 mL per 1,000 lbs. - and just one injection per day1
(2.6 mL/1,250 lbs.; 1.5 mL/750 lbs.).

  1. EQUIOXX product label.

EQUIOXX Oral Paste is convenient and can easily be administered by horse owners, which can be important for compliance, and therefore, results.

Every horse is unique and may respond differently to various NSAIDs (just as humans do). EQUIOXX provides consistent pain relief* for 24 hours with just one daily dose.1

*Joint pain and inflammation associated with equine osteoarthritis, also called degenerative joint disease.

  1. EQUIOXX product labels.

Many times, equine NSAIDs are only used once a day for convenience or due to medication testing compliance. With products that aren’t meant to be used once a day, this may result in a roller-coaster effect of pain and pain relief.1

  1. Phenylbutazone Tablets, Le Sueur, MN: Vet One, 2006.

As with any other medication that you haven’t used for your horse before, talk to your veterinarian about the best way to use EQUIOXX. If your veterinarian has more questions, have them call Merial and speak with one of our veterinarians on staff.

Your horse should not be given EQUIOXX if it:

  • Has had an allergic reaction to firocoxib, the active ingredient in EQUIOXX.
  • Has previously had an allergic reaction (such as hives, facial or lower limb swelling, or red or itchy skin) to aspirin or other NSAIDs.
  • Is presently taking aspirin, phenylbutazone, flunixin meglumine, diclofenac, ketoprofen, or other NSAIDs or corticosteroids. The safety of EQUIOXX has not been determined in horses less than one year of age or in breeding horses, pregnant or lactating mares.

As a general rule, neither EQUIOXX nor other NSAIDs should be used in conjunction with other NSAIDs (for example, aspirin, phenylbutazone, diclofenac, ketoprofen or flunixin) or systemic corticosteroids (for example, prednisone, cortisone, dexamethasone or triamcinolone).

Tell your veterinarian about all medications you have given your horse in the past and any medications you are planning to give with EQUIOXX Oral Paste. This should include other medicines that you can get without a prescription or any dietary supplements. Your veterinarian may want to check that all of your horse’s medicines can be given together.

Consult your veterinarian if your horse receives more than the prescribed amount of EQUIOXX.

Nearly every show organization has their own rules and regulations about the use of NSAIDs during competition – so be sure to check with the governing body of an event before using any medication.

Both the USEF and AQHA (and many of the groups that use these organizations for their guidelines) have approved the use of EQUIOXX at the recommended dose 12 hours prior to competition. Furthermore, EQUIOXX is the only NSAID approved for use up to 14 successive days by these two groups. For other associations, rules may vary, so be sure to check before using EQUIOXX. Below are some links to various organizations’ websites where you can find their medication rules:

ABOUT EQUINE OSTEOARTHRITIS

Equine osteoarthritis is a chronic disease that causes degeneration of the joints, resulting in pain, inflammation and reduced mobility. It can affect any joint in your horse’s body.

Trauma to the joint, conformation, age and improper shoeing are some of the typical causes of equine OA.

  • Limping or lameness.
  • Decreased activity or exercise (reluctance to stand, walk, trot or canter, or difficulty performing these activities).
  • Stiffness or decreased movement of joints.
  • If you suspect your horse is suffering from joint pain, ask your veterinarian to examine your
    horse. Your veterinarian can perform a lameness evaluation and will possibly recommend x-
    rays, ultrasounds or other diagnostics.
  • Should OA be diagnosed, ask for information about treatment for the pain and inflammation
    associated with osteoarthritis, including EQUIOXX® (firocoxib).
  • Follow your veterinarian’s recommendations.

In addition to observing your horse during a routine lameness examination, your
veterinarian has several diagnostic tools available for determining whether your horse
has arthritis, including:

  • Nerve and joint blocks
  • Radiographs
  • Ultrasound
  • Thermography
  • Fluoroscopy
  • Nuclear scintigraphy
  • CT
  • MRI

Unfortunately, there is no definitive cure for OA in horses, but the pain and inflammation
associated with equine osteoarthritis can be treated.

Treatment for equine OA focuses on alleviating pain and inflammation in the joint which
may allow your horse to have increased mobility.

Ask your veterinarian for more information about treating the pain and inflammation
associated with equine osteoarthritis with EQUIOXX.